Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function.

PURPOSE: Monoclonal antibodies (mAb) are used to treat solid and hematological malignancies, and work in part through Fc receptors (FcR) on natural killer cells (NK). However, FcR mediated functions of NK cells from cancer patients are significantly impaired. Identifying the mechanisms of this dysfu...

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Udgivet i:Clin Cancer Res
Main Authors: Stiff, Andrew, Trikha, Prashant, Mundy-Bosse, Bethany, McMichael, Elizabeth, Mace, Thomas A., Benner, Brooke, Kendra, Kari, Campbell, Amanda, Gautam, Shalini, Abood, David, Landi, Ian, Hsu, Vincent, Duggan, Megan, Wesolowski, Robert, Old, Matthew, Howard, John Harrison, Yu, Lianbo, Stasik, Nancy, Olencki, Thomas, Muthusamy, Natarajan, Tridandapani, Susheela, Byrd, John C., Caligiuri, Michael, Carson, William E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184799/
https://ncbi.nlm.nih.gov/pubmed/29363526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0691
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