Myeloid-derived suppressor cells express Bruton’s tyrosine kinase and can be depleted in tumor bearing hosts by ibrutinib treatment

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells that expand in tumor bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-b...

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Published in:Cancer Res
Main Authors: Stiff, Andrew, Trikha, Prashant, Wesolowski, Robert, Kendra, Kari, Hsu, Vincent, Uppati, Sarvani, McMichael, Elizabeth, Duggan, Megan, Campbell, Amanda, Keller, Karen, Landi, Ian, Zhong, Yiming, Dubovsky, Jason, Howard, John Harrison, Yu, Lianbo, Harrington, Bonnie, Old, Matthew, Reiff, Sean, Mace, Thomas, Tridandapani, Susheela, Muthusamy, Natarajan, Caligiuri, Michael A., Byrd, John C., Carson, William E.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873459/
https://ncbi.nlm.nih.gov/pubmed/26880800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1490
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