Myeloid-derived suppressor cells express Bruton’s tyrosine kinase and can be depleted in tumor bearing hosts by ibrutinib treatment

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells that expand in tumor bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-b...

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Publicat a:Cancer Res
Autors principals: Stiff, Andrew, Trikha, Prashant, Wesolowski, Robert, Kendra, Kari, Hsu, Vincent, Uppati, Sarvani, McMichael, Elizabeth, Duggan, Megan, Campbell, Amanda, Keller, Karen, Landi, Ian, Zhong, Yiming, Dubovsky, Jason, Howard, John Harrison, Yu, Lianbo, Harrington, Bonnie, Old, Matthew, Reiff, Sean, Mace, Thomas, Tridandapani, Susheela, Muthusamy, Natarajan, Caligiuri, Michael A., Byrd, John C., Carson, William E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873459/
https://ncbi.nlm.nih.gov/pubmed/26880800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1490
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