Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

BACKGROUND: Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several wasting s...

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Vydáno v:Skelet Muscle
Hlavní autoři: Nguyen, Thanh, Bowen, T. Scott, Augstein, Antje, Schauer, Antje, Gasch, Alexander, Linke, Axel, Labeit, Siegfried, Adams, Volker
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184701/
https://ncbi.nlm.nih.gov/pubmed/32340625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-020-00229-2
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