Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

BACKGROUND: Chronic heart failure (CHF) leads to diaphragm myopathy that significantly impairs quality of life and worsens prognosis. In this study, we aimed to assess the efficacy of a recently discovered small‐molecule inhibitor of MuRF1 in treating CHF‐induced diaphragm myopathy and loss of contr...

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Detalhes bibliográficos
Publicado no:J Cachexia Sarcopenia Muscle
Main Authors: Adams, Volker, Bowen, T. Scott, Werner, Sarah, Barthel, Peggy, Amberger, Christina, Konzer, Anne, Graumann, Johannes, Sehr, Peter, Lewis, Joe, Provaznik, Jan, Benes, Vladimir, Büttner, Petra, Gasch, Alexander, Mangner, Norman, Witt, Christian C., Labeit, Dittmar, Linke, Axel, Labeit, Siegfried
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818456/
https://ncbi.nlm.nih.gov/pubmed/31140761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12448
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