Small‐molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia

BACKGROUND: Muscle ring finger 1 (MuRF1) is a muscle‐specific ubiquitin E3 ligase activated during clinical conditions associated with skeletal muscle wasting. Yet, there remains a paucity of therapeutic interventions that directly inhibit MuRF1 function, particularly in vivo. The current study, the...

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Bibliographic Details
Published in:J Cachexia Sarcopenia Muscle
Main Authors: Bowen, Thomas Scott, Adams, Volker, Werner, Sarah, Fischer, Tina, Vinke, Paulien, Brogger, Maria Noel, Mangner, Norman, Linke, Axel, Sehr, Peter, Lewis, Joe, Labeit, Dittmar, Gasch, Alexander, Labeit, Siegfried
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700443/
https://ncbi.nlm.nih.gov/pubmed/28887874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12233
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