Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

BACKGROUND: Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several wasting s...

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Bibliografske podrobnosti
izdano v:Skelet Muscle
Main Authors: Nguyen, Thanh, Bowen, T. Scott, Augstein, Antje, Schauer, Antje, Gasch, Alexander, Linke, Axel, Labeit, Siegfried, Adams, Volker
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184701/
https://ncbi.nlm.nih.gov/pubmed/32340625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-020-00229-2
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