Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

BACKGROUND: Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several wasting s...

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Enregistré dans:
Détails bibliographiques
Publié dans:Skelet Muscle
Auteurs principaux: Nguyen, Thanh, Bowen, T. Scott, Augstein, Antje, Schauer, Antje, Gasch, Alexander, Linke, Axel, Labeit, Siegfried, Adams, Volker
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184701/
https://ncbi.nlm.nih.gov/pubmed/32340625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-020-00229-2
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