The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair

OBJECTIVE: This study aims to explore the role of MARK2 in chemotherapeutic resistance and potential mechanism within cisplatin resistance models of CD133(+) MG-63 and MNNG/HOS cells. METHODS: CD133(−) and CD133(+) MG-63 and MNNG/HOS cells were differentiated and obtained by MACS(Magnetic bead sorti...

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Publicado en:J Bone Oncol
Autores principales: Xu, Liang, Sun, Zhengkao, Wei, Xianfu, Tan, Hongdong, Kong, Peng, Li, Zhenfeng, Yang, Qiang, Dai, E'nuo, Li, Jianmin
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184251/
https://ncbi.nlm.nih.gov/pubmed/32368441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2020.100290
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