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Enhancing Therapeutic Efficacy of Cisplatin by Blocking DNA Damage Repair

[Image: see text] Self-repair of nuclear DNA damage is the most known reason that leads to drug resistance of cancer tissue and limited therapeutic efficacy of anticancer drugs. Inhibition of protein phosphatase 2A (PP2A) would block DNA damage-induced defense of cancer cells to suppress DNA repair...

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Dettagli Bibliografici
Pubblicato in:ACS Med Chem Lett
Autori principali: Cong, Yuwei, Wang, Liangyan, Wang, Zigui, He, Shasha, Zhou, Dongfang, Jing, Xiabin, Huang, Yubin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066156/
https://ncbi.nlm.nih.gov/pubmed/27774130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00236
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