Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma

BACKGROUND: SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might be involved in resistance to anti-cancer therapy. METHODS: We evaluated the prognostic significance of SIRT6 in 37 osteosa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhang, Zhongkai, Ha, Sang Hoon, Moon, Young Jae, Hussein, Usama Khamis, Song, Yiping, Kim, Kyoung Min, Park, See-Hyoung, Park, Ho Sung, Park, Byung-Hyun, Ahn, Ae-Ri, Lee, Sang-A, Ahn, Su Jin, Kim, Jung Ryul, Jang, Kyu Yun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670730/
https://ncbi.nlm.nih.gov/pubmed/33198792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01759-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados