Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells

Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance. In addition to its telomere maintenance function, telomerase plays a pro-survival role, inducing decrease...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Zhang, Zhengpei, Yu, Ling, Dai, Guo, Xia, Kezhou, Liu, Gaiwei, Song, Qi, Tao, Chunjie, Gao, Tian, Guo, Weichun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539325/
https://ncbi.nlm.nih.gov/pubmed/28765565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07204-w
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