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Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

OBJECTIVE: The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A systematic multi-omics analysis of GH effects in the liver has not been performed. GH receptor (GHR) deficiency is...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Riedel, Evamaria O., Hinrichs, Arne, Kemter, Elisabeth, Dahlhoff, Maik, Backman, Mattias, Rathkolb, Birgit, Prehn, Cornelia, Adamski, Jerzy, Renner, Simone, Blutke, Andreas, de Angelis, Martin Hrabĕ, Bidlingmaier, Martin, Schopohl, Jochen, Arnold, Georg J., Fröhlich, Thomas, Wolf, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184181/
https://ncbi.nlm.nih.gov/pubmed/32277923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100978
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