Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity

Background and aims: Fasting hypoglycemia has clinical implications for children with growth hormone (GH)-insensitivity syndrome. This study investigates the pathophysiology of juvenile hypoglycemia in a large animal model for GH receptor (GHR) deficiency (the GHR-KO pig) and elucidates mechanisms u...

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Detalhes bibliográficos

Principais autores:	Arne Hinrichs, Kalliopi Pafili, Gencer Sancar, Laeticia Laane, Silja Zettler, Malek Torgeman, Barbara Kessler, Judith Leonie Nono, Sonja Kunz, Birgit Rathkolb, Cristina Barosa, Cornelia Prehn, Alexander Cecil, Simone Renner, Elisabeth Kemter, Sabine Kahl, Julia Szendroedi, Martin Bidlingmaier, John Griffith Jones, Martin Hrabĕ de Angelis, Michael Roden, Eckhard Wolf
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
coleção:	Molecular Metabolism
Assuntos:	GH insensitivity Hypoglycemia Insulin sensitivity Large animal model Glucose metabolism Beta-oxidation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877825001802
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