PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex

The invasive behavior of glioblastoma is essential to its aggressive potential. Here, we show that pleckstrin homology domain interacting protein (PHIP), acting through effects on the force transduction layer of the focal adhesion complex, drives glioblastoma motility and invasion. Immunofluorescenc...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: de Semir, David, Bezrookove, Vladimir, Nosrati, Mehdi, Scanlon, Kara R., Singer, Eric, Judkins, Jonathon, Rieken, Christopher, Wu, Clayton, Shen, Julia, Schmudermayer, Christina, Dar, Altaf A., Miller, James R., Cobbs, Charles, Yount, Garret, Desprez, Pierre-Yves, Debs, Robert J., Salomonis, Nathan, McAllister, Sean, Cleaver, James E., Soroceanu, Liliana, Kashani-Sabet, Mohammed
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183218/
https://ncbi.nlm.nih.gov/pubmed/32273388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914505117
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