PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex

The invasive behavior of glioblastoma is essential to its aggressive potential. Here, we show that pleckstrin homology domain interacting protein (PHIP), acting through effects on the force transduction layer of the focal adhesion complex, drives glioblastoma motility and invasion. Immunofluorescenc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: de Semir, David, Bezrookove, Vladimir, Nosrati, Mehdi, Scanlon, Kara R., Singer, Eric, Judkins, Jonathon, Rieken, Christopher, Wu, Clayton, Shen, Julia, Schmudermayer, Christina, Dar, Altaf A., Miller, James R., Cobbs, Charles, Yount, Garret, Desprez, Pierre-Yves, Debs, Robert J., Salomonis, Nathan, McAllister, Sean, Cleaver, James E., Soroceanu, Liliana, Kashani-Sabet, Mohammed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183218/
https://ncbi.nlm.nih.gov/pubmed/32273388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914505117
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