Rho-kinase ROCK inhibitors reduce oligomeric tau protein

Neurofibrillary tangles, one of the pathological hallmarks of Alzheimer’s disease, consist of highly phosphorylated tau proteins. Tau protein binds to microtubules and is best known for its role in regulating microtubule dynamics. However, if tau protein is phosphorylated by activated major tau kina...

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Udgivet i:Neurobiol Aging
Main Authors: Hamano, Tadanori, Shirafuji, Norimichi, Yen, Shu-Hui, Yoshida, Hirotaka, Kanaan, Nicholas M., Hayashi, Kouji, Ikawa, Masamichi, Yamamura, Osamu, Fujita, Youshi, Kuriyama, Masaru, Nakamoto, Yasunari
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183001/
https://ncbi.nlm.nih.gov/pubmed/31982202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.12.009
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