Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization

Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer’s disease (AD) and vascular dementia. However, the reason elevated plasma homocysteinemia increases the risk of dementia remains unknown. A pathological hallmark of AD is neurofibrillary tangles (NFTs) that...

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Udgivet i:Int J Mol Sci
Main Authors: Shirafuji, Norimichi, Hamano, Tadanori, Yen, Shu-Hui, Kanaan, Nicholas M., Yoshida, Hirotaka, Hayashi, Kouji, Ikawa, Masamichi, Yamamura, Osamu, Kuriyama, Masaru, Nakamoto, Yasunari
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877752/
https://ncbi.nlm.nih.gov/pubmed/29562600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19030891
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