TALEN mediated gene editing in a mouse model of Fanconi anemia

The promising ability to genetically modify hematopoietic stem and progenitor cells by precise gene editing remains challenging due to their sensitivity to in vitro manipulations and poor efficiencies of homologous recombination. This study represents the first evidence of implementing a gene editin...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Pino-Barrio, Maria José, Giménez, Yari, Villanueva, Mariela, Hildenbeutel, Marcus, Sánchez-Dominguez, Rebeca, Rodríguez-Perales, Sandra, Pujol, Roser, Surrallés, Jordi, Río, Paula, Cathomen, Toni, Mussolino, Claudio, Bueren, Juan Antonio, Navarro, Susana
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181878/
https://ncbi.nlm.nih.gov/pubmed/32332829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63971-z
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