TALEN mediated gene editing in a mouse model of Fanconi anemia

The promising ability to genetically modify hematopoietic stem and progenitor cells by precise gene editing remains challenging due to their sensitivity to in vitro manipulations and poor efficiencies of homologous recombination. This study represents the first evidence of implementing a gene editin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pino-Barrio, Maria José, Giménez, Yari, Villanueva, Mariela, Hildenbeutel, Marcus, Sánchez-Dominguez, Rebeca, Rodríguez-Perales, Sandra, Pujol, Roser, Surrallés, Jordi, Río, Paula, Cathomen, Toni, Mussolino, Claudio, Bueren, Juan Antonio, Navarro, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181878/
https://ncbi.nlm.nih.gov/pubmed/32332829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63971-z
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