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DNA:RNA hybrids form at DNA double-strand breaks in transcriptionally active loci

The recent discovery of DNA:RNA hybrids, or R-loops, actively forming at DNA double-strand breaks (DSBs) has unlocked fresh insight into how RNA participates in DNA repair. However, the manner of DSB-induced R-loop formation is vital in determining its mechanism of action and is currently under deba...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Bader, Aldo S., Bushell, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181826/
https://ncbi.nlm.nih.gov/pubmed/32332801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2464-6
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