Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a putative RNA:DNA helicase involved in transcription and in the maintenance of genome integrity. Here, using ChIP followed by h...

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Udgivet i:Nat Commun
Main Authors: Cohen, Sarah, Puget, Nadine, Lin, Yea-Lih, Clouaire, Thomas, Aguirrebengoa, Marion, Rocher, Vincent, Pasero, Philippe, Canitrot, Yvan, Legube, Gaëlle
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803260/
https://ncbi.nlm.nih.gov/pubmed/29416069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02894-w
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