Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contri...

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Détails bibliographiques
Publié dans:Acta Neuropathol
Auteurs principaux: Rawji, Khalil S., Young, Adam M.H., Ghosh, Tanay, Michaels, Nathan J., Mirzaei, Reza, Kappen, Janson, Kolehmainen, Kathleen L., Alaeiilkhchi, Nima, Lozinski, Brian, Mishra, Manoj K., Pu, Annie, Tang, Weiwen, Zein, Salma, Kaushik, Deepak K., Keough, Michael B., Plemel, Jason R., Calvert, Fiona, Knights, Andrew J., Gaffney, Daniel J., Tetzlaff, Wolfram, Franklin, Robin J. M., Yong, V. Wee
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2020
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181452/
https://ncbi.nlm.nih.gov/pubmed/32030468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02129-7
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