Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contri...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Rawji, Khalil S., Young, Adam M.H., Ghosh, Tanay, Michaels, Nathan J., Mirzaei, Reza, Kappen, Janson, Kolehmainen, Kathleen L., Alaeiilkhchi, Nima, Lozinski, Brian, Mishra, Manoj K., Pu, Annie, Tang, Weiwen, Zein, Salma, Kaushik, Deepak K., Keough, Michael B., Plemel, Jason R., Calvert, Fiona, Knights, Andrew J., Gaffney, Daniel J., Tetzlaff, Wolfram, Franklin, Robin J. M., Yong, V. Wee
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181452/
https://ncbi.nlm.nih.gov/pubmed/32030468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02129-7
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