Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show t...

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Pubblicato in:Cell Stem Cell
Autori principali: Neumann, Björn, Baror, Roey, Zhao, Chao, Segel, Michael, Dietmann, Sabine, Rawji, Khalil S., Foerster, Sarah, McClain, Crystal R., Chalut, Kevin, van Wijngaarden, Peter, Franklin, Robin J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863391/
https://ncbi.nlm.nih.gov/pubmed/31585093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.015
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