Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show t...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Neumann, Björn, Baror, Roey, Zhao, Chao, Segel, Michael, Dietmann, Sabine, Rawji, Khalil S., Foerster, Sarah, McClain, Crystal R., Chalut, Kevin, van Wijngaarden, Peter, Franklin, Robin J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863391/
https://ncbi.nlm.nih.gov/pubmed/31585093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.015
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