Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show t...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Neumann, Björn, Baror, Roey, Zhao, Chao, Segel, Michael, Dietmann, Sabine, Rawji, Khalil S., Foerster, Sarah, McClain, Crystal R., Chalut, Kevin, van Wijngaarden, Peter, Franklin, Robin J.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863391/
https://ncbi.nlm.nih.gov/pubmed/31585093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.015
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