Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Ex Vivo Live Multiphoton Imaging

Aging impairs regenerative processes including remyelination, the synthesis of a new myelin sheath. Microglia and other infiltrating myeloid cells such as macrophages are essential for remyelination through mechanisms that include the clearance of inhibitory molecules within the lesion. Prior studie...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Rawji, Khalil S., Kappen, Janson, Tang, Weiwen, Teo, Wulin, Plemel, Jason R., Stys, Peter K., Yong, V. Wee
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705888/
https://ncbi.nlm.nih.gov/pubmed/29363580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2341-17.2018
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