Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [(18)F]AlF-Affibody Conjugates

Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting bioconjugates are subsequently radiolabeled, instability has been observed both durin...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Da Pieve, Chiara, Makarem, Ata, Turnock, Stephen, Maczynska, Justyna, Smith, Graham, Kramer-Marek, Gabriela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180749/
https://ncbi.nlm.nih.gov/pubmed/32235296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071562
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