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A Novel Bifunctional Maleimido CHX-A” Chelator for Conjugation to Thiol-Containing Biomolecules
A novel bifunctional maleimido CHX-A”-DTPA chelator 5 was developed and conjugated to the monoclonal antibody trastuzumab (Herceptin) and subsequently radiolabeled with (111)In. The resulting (111)In labeled immunoconjugate 2 was demonstrated to bind to SKOV3 ovarian cancer cells comparably to an is...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2346453/ https://ncbi.nlm.nih.gov/pubmed/18359632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.022 |
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