Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Komine, Hibiki, Mori, Shohei, Morihiro, Kunihiko, Ishida, Kenta, Okuda, Takumi, Kasahara, Yuuya, Aoyama, Hiroshi, Yamaguchi, Takao, Obika, Satoshi
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180610/
https://ncbi.nlm.nih.gov/pubmed/32283778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071732
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