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Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

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Bibliografiske detaljer
Udgivet i:Beilstein J Org Chem
Main Authors: Horie, Naohiro, Yamaguchi, Takao, Kumagai, Shinji, Obika, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940814/
https://ncbi.nlm.nih.gov/pubmed/33747234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.17.54
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