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Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

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Podrobná bibliografie
Vydáno v:Beilstein J Org Chem
Hlavní autoři: Horie, Naohiro, Yamaguchi, Takao, Kumagai, Shinji, Obika, Satoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Beilstein-Institut 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940814/
https://ncbi.nlm.nih.gov/pubmed/33747234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.17.54
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