Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Pubblicato in:Molecules
Autori principali: Komine, Hibiki, Mori, Shohei, Morihiro, Kunihiko, Ishida, Kenta, Okuda, Takumi, Kasahara, Yuuya, Aoyama, Hiroshi, Yamaguchi, Takao, Obika, Satoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180610/
https://ncbi.nlm.nih.gov/pubmed/32283778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071732
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