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Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers.

A Cu-catalyzed method for the efficient enantio- and diastereoselective synthesis of chiral homoallylic amines bearing a quaternary carbon and an alkenylboron is disclosed. Transformations are promoted by a readily prepared (phosphoramidite)–Cu complex, and involve bench-stable γ-disubstituted allyl...

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Pubblicato in:J Am Chem Soc
Autori principali: Green, Jacob C., Zanghi, Joseph M., Meek, Simon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180160/
https://ncbi.nlm.nih.gov/pubmed/31934766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11529
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