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An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1

Direct measurement of DNA repair enzyme activities is important both for basic study of cellular repair pathways as well as for potential new translational applications in their associated diseases. NTH1, a major glycosylase targeting oxidized pyrimidines, prevents mutations arising from this damage...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Jun, Yong Woong, Wilson, David L., Kietrys, Anna M., Lotsof, Elizabeth R., Conlon, Savannah G., David, Sheila S., Kool, Eric T.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180134/
https://ncbi.nlm.nih.gov/pubmed/32109332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202001516
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