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Initiation of Base Excision Repair of Oxidative Lesions in Nucleosomes by the Human, Bifunctional DNA Glycosylase NTH1

Oxidative lesions account for much of the spontaneously occurring DNA damage in normal cells and, left unrepaired, can be mutagenic or cytotoxic. We have investigated the capacity of purified human enzymes to initiate the base excision repair (BER) of oxidative lesions in model nucleosomes. In a con...

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Detalles Bibliográficos
Main Authors: Prasad, Amalthiya, Wallace, Susan S., Pederson, David S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169407/
https://ncbi.nlm.nih.gov/pubmed/17923696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00791-07
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