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Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes
Reactive oxygen species generate ~20,000 oxidative lesions in the DNA of every cell, every day. Most of these lesions are located within nucleosomes, which package DNA in chromatin and impede base excision repair (BER). We demonstrated previously that periodic, spontaneous partial unwrapping of DNA...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877670/ https://ncbi.nlm.nih.gov/pubmed/24051050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.08.010 |
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