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UV Damage in DNA Promotes Nucleosome Unwrapping

The association of DNA with histones in chromatin impedes DNA repair enzymes from accessing DNA lesions. Nucleosomes exist in a dynamic equilibrium in which portions of the DNA molecule spontaneously unwrap, transiently exposing buried DNA sites. Thus, nucleosome dynamics in certain regions of chrom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Duan, Ming-Rui, Smerdon, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924050/
https://ncbi.nlm.nih.gov/pubmed/20562439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.140087
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