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Initiation of Base Excision Repair of Oxidative Lesions in Nucleosomes by the Human, Bifunctional DNA Glycosylase NTH1

Oxidative lesions account for much of the spontaneously occurring DNA damage in normal cells and, left unrepaired, can be mutagenic or cytotoxic. We have investigated the capacity of purified human enzymes to initiate the base excision repair (BER) of oxidative lesions in model nucleosomes. In a con...

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Autors principals: Prasad, Amalthiya, Wallace, Susan S., Pederson, David S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169407/
https://ncbi.nlm.nih.gov/pubmed/17923696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00791-07
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