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Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam

Resistance to ceftazidime-avibactam due to mutations in KPC genes has been reported both in vitro and in clinical settings. The most frequently reported mutation leads to the amino acid substitution D179Y in the Ω loop of the enzyme. Bacterial cells that carry mutant KPC acquire a higher level of ce...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Tsivkovski, Ruslan, Lomovskaya, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179312/
https://ncbi.nlm.nih.gov/pubmed/32015028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01936-19
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