Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias

Ryanodine receptor 2 (RyR2) and SERCA2a are two major players in myocyte calcium (Ca) cycling that are modulated physiologically, affected by disease and thus considered to be potential targets for cardiac disease therapy. However, how RyR2 and SERCA2a influence each others’ activities, as well as t...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Liu, Bin, Lou, Qing, Smith, Heather, Velez-Cortes, Florencia, Dillmann, Wolfgang H., Knollmann, Björn C., Armoundas, Antonis A., Györke, Sándor
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178036/
https://ncbi.nlm.nih.gov/pubmed/32260593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072535
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