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Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytotoxic selectivity between leukemic cell lines and h...

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Publicado en:Int J Mol Sci
Autores principales: Chan, She-Hung, Leu, Wohn-Jenn, Swain, Sharada Prasanna, Hsu, Jui-Ling, Hou, Duen-Ren, Guh, Jih-Hwa
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177546/
https://ncbi.nlm.nih.gov/pubmed/32252439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072470
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