Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodiesterase type 5 (PDE5) inhibitor, has been suggeste...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Hsu, Jui-Ling, Leu, Wohn-Jenn, Hsu, Lih-Ching, Ho, Chen-Hsun, Liu, Shih-Ping, Guh, Jih-Hwa
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427565/
https://ncbi.nlm.nih.gov/pubmed/32850387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01274
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