Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

A series of triazole-based small molecules that mimic FTY720-mediated anticancer activity but minimize its immunosuppressive effect have been produced. SPS-7 is the most effective derivative displaying higher activity than FTY720 in anti-proliferation against human hormone-refractory prostate cancer...

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Vydáno v:Oncotarget
Hlavní autoři: Leu, Wohn-Jenn, Swain, Sharada Prasanna, Chan, She-Hung, Hsu, Jui-Ling, Liu, Shih-Ping, Chan, Mei-Ling, Yu, Chia-Chun, Hsu, Lih-Ching, Chou, Yen-Lin, Chang, Wei-Ling, Hou, Duen-Ren, Guh, Jih-Hwa
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363565/
https://ncbi.nlm.nih.gov/pubmed/27769069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12765
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