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Development of a Yeast Two-Hybrid Screen for Selection of Human Ras-Raf Protein Interaction Inhibitors

A yeast two-hybrid screening system was developed to screen for small molecules that inhibit the interaction of the Ras and the Raf proteins. Hyperpermeable yeast strains useful for high-throughput screening (HTS) for the two-hybrid system were created. Differential inhibition of the Ras-Raf vs the...

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Foilsithe in:Chemical Genomics
Main Authors: Khazak, Vladimir, Golemis, Erica A., Weber, Lutz
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2005
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177006/
https://ncbi.nlm.nih.gov/pubmed/16353379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-59259-948-6_18
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