Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

BACKGROUND: Activation of the mammalian Ras-Raf-MEK-ERK MAPK signaling cascade promotes cellular proliferation, and activating Ras mutations are implicated in cancer onset and maintenance. This pathway, a therapeutic target of interest, is highly conserved and required for vulval development in C. e...

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Autores principales: González-Pérez, Vanessa, Reiner, David J, Alan, Jamie K, Mitchell, Cicely, Edwards, Lloyd J, Khazak, Vladimir, Der, Channing J, Cox, Adrienne D
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848644/
https://ncbi.nlm.nih.gov/pubmed/20178605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-5-2
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