Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21(+/-) mice to mimic...

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Pubblicato in:eLife
Autori principali: Alcott, Callison E, Yalamanchili, Hari Krishna, Ji, Ping, van der Heijden, Meike E, Saltzman, Alexander, Elrod, Nathan, Lin, Ai, Leng, Mei, Bhatt, Bhoomi, Hao, Shuang, Wang, Qi, Saliba, Afaf, Tang, Jianrong, Malovannaya, Anna, Wagner, Eric J, Liu, Zhandong, Zoghbi, Huda Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Genetics and Genomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176433/
https://ncbi.nlm.nih.gov/pubmed/32319885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50895
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