Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation

Systemic sclerosis (SSc; scleroderma) is a multisystem fibrotic disease. The mammalian cleavage factor I 25-kD subunit (CFIm25; encoded by NUDT21) is a key regulator of alternative polyadenylation, and its depletion causes predominantly 3′UTR shortening through loss of stimulation of distal polyaden...

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Pubblicato in:J Exp Med
Autori principali: Weng, Tingting, Huang, Jingjing, Wagner, Eric J., Ko, Junsuk, Wu, Minghua, Wareing, Nancy E., Xiang, Yu, Chen, Ning-Yuan, Ji, Ping, Molina, Jose G., Volcik, Kelly A., Han, Leng, Mayes, Maureen D., Blackburn, Michael R., Assassi, Shervin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041714/
https://ncbi.nlm.nih.gov/pubmed/31757866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181384
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