STING couples with PI3K to regulate actin reorganization during BCR activation

The adaptor protein, STING (stimulator of interferon genes), has been rarely studied in adaptive immunity. We used Sting KO mice and a patient’s mutated STING cells to study the effect of STING deficiency on B cell development, differentiation, and BCR signaling. We found that STING deficiency promo...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Jing, Yukai, Dai, Xin, Yang, Lu, Kang, Danqing, Jiang, Panpan, Li, Na, Cheng, Jiali, Li, Jingwen, Miller, Heather, Ren, Boxu, Gong, Quan, Yin, Wei, Liu, Zheng, Mattila, Pieta K., Ning, Qin, Sun, Jinqiao, Yu, Bing, Liu, Chaohong
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176427/
https://ncbi.nlm.nih.gov/pubmed/32494627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9455
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