Structural basis for the docking of mTORC1 on the lysosomal surface

The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)–Ragulator complex. Nutri...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Rogala, Kacper B., Gu, Xin, Kedir, Jibril F., Abu-Remaileh, Monther, Bianchi, Laura F., Bottino, Alexia M. S., Dueholm, Rikke, Niehaus, Anna, Overwijn, Daan, Fils, Ange-Célia Priso, Zhou, Sherry X., Leary, Daniel, Laqtom, Nouf N., Brignole, Edward J., Sabatini, David M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176403/
https://ncbi.nlm.nih.gov/pubmed/31601708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0166
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