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Structural basis for the docking of mTORC1 on the lysosomal surface

The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)–Ragulator complex. Nutri...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Rogala, Kacper B., Gu, Xin, Kedir, Jibril F., Abu-Remaileh, Monther, Bianchi, Laura F., Bottino, Alexia M. S., Dueholm, Rikke, Niehaus, Anna, Overwijn, Daan, Fils, Ange-Célia Priso, Zhou, Sherry X., Leary, Daniel, Laqtom, Nouf N., Brignole, Edward J., Sabatini, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176403/
https://ncbi.nlm.nih.gov/pubmed/31601708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0166
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