Intellectual disability-associated SMARCB1 mutations reveal a nucleosome acidic patch interaction site that potentiates mSWI/SNF chromatin remodeling

Mammalian SWI/SNF (BAF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain- specific contributions to complex activities is required to advance mechanistic understanding. Here we examine the molecular, structural, and genome-wide regulat...

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Publicado no:Cell
Main Authors: Valencia, Alfredo M., Collings, Clayton K., Dao, Hai T., Pierre, Roodolph St., Cheng, Yung-Chih, Huang, Junwei, Sun, Zhen-Yu, Seo, Hyuk-Soo, Mashtalir, Nazar, Comstock, Dawn E., Bolonduro, Olubusayo, Vangos, Nicholas E., Yeoh, Zoe C., Dornon, Mary Kate, Hermawan, Crystal, Barrett, Lee, Dhe-Paganon, Sirano, Woolf, Clifford J., Muir, Tom W., Kadoch, Cigall
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175411/
https://ncbi.nlm.nih.gov/pubmed/31759698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.044
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